SCHEMBL30528940

SCHEMBL30528940

CCOc1cncc(-c2ccc(NC(=O)C(C)(C)c3csc(NS(=O)(=O)C4CC4)n3)c(C(F)(F)F)c2)n1

nearest known ligand 0.69

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CTPS1 P17812 20/20 0.69
CTPS2 Q9NRF8 2/20 0.69

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22491636 1.00 CTPS1 (0.69) CTPS1CTPS2
SCHEMBL30528971 0.91 CTPS1 (0.77) CTPS1CTPS2
SCHEMBL21044547 0.91 CTPS1 (0.77) CTPS1CTPS2
SCHEMBL21044352 0.91 CTPS1 (0.71) CTPS1CTPS2
SCHEMBL30529020 0.91 CTPS1 (0.71) CTPS1CTPS2
SCHEMBL30528765 0.91 CTPS1 (0.55) CTPS1CTPS2
SCHEMBL22491759 0.91 CTPS1 (0.55) CTPS1CTPS2
SCHEMBL30528997 0.89 CTPS1 (0.63) CTPS1CTPS2
SCHEMBL22491721 0.89 CTPS1 (0.63) CTPS1CTPS2
SCHEMBL22491745 0.89 CTPS1 (0.85) CTPS1CTPS2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3717459-B1 COMPOUNDS STEP PHARMA S A S (FR) 2026-01-21 EP claimed
EP-4637770-A1 CTPS1 INHIBITORS FOR USE IN THE TREATMENT OF CTPS2 DEFICIENT CANCER Step Pharma S.A.S. (FR) 2025-10-29 EP disclosed
CN-118804752-A Combination of CTPS1 and BCL2 inhibitors for the treatment of cancer 斯泰普制药股份公司 2024-10-18 CN disclosed
WO-2024133721-A1 COMBINATIONS OF CTPS1 INHIBITOR WITH IAP INHIBITOR FOR USE IN THE TREATMENT OF CANCER STEP PHARMA S.A.S. (FR) 2024-06-27 WO disclosed
WO-2023166080-A1 COMBINATION TREATMENTS COMPRISING A CTPS1 INHIBITOR AND A WEE1 INHIBITOR STEP PHARMA S.A.S. (FR) 2023-09-07 WO disclosed
WO-2023166078-A1 COMBINATION TREATMENTS COMPRISING A CTPS1 INHIBITOR AND A CHEK1 INHIBITOR STEP PHARMA S.A.S. (FR) 2023-09-07 WO disclosed