Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNK | O75909 | 13/20 | 0.49 |
| ▸ | CDK12 | Q9NYV4 | 13/20 | 0.49 |
| ▸ | CCNA2 | P20248 | 10/20 | 0.44 |
| ▸ | CDK2 | P24941 | 10/20 | 0.44 |
| ▸ | CDK7 | P50613 | 10/20 | 0.44 |
| ▸ | CCNH | P51946 | 10/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 10/20 | 0.44 |
| ▸ | EGFR | P00533 | 1/20 | 0.39 |
| ▸ | FGFR4 | P22455 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25216702 | 1.00 | CCNK (0.49) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL25224265 | 1.00 | CCNK (0.49) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL30533851 | 1.00 | CCNK (0.49) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL25233481 | 1.00 | CCNK (0.49) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL25221183 | 0.88 | CCNK (0.44) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL30464490 | 0.88 | CCNK (0.44) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL25268712 | 0.88 | CCNK (0.44) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL30464385 | 0.88 | CCNK (0.44) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL25273470 | 0.86 | CCNK (0.57) | CCNKCDK12CCNA2CDK2CDK7 | |
| SCHEMBL25273469 | 0.86 | CCNK (0.57) | CCNKCDK12CCNA2CDK2CDK7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | claimed |
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |