Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK12 | Q9NYV4 | 14/20 | 0.53 |
| ▸ | CCNK | O75909 | 13/20 | 0.53 |
| ▸ | CDK13 | Q14004 | 1/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 8/20 | 0.40 |
| ▸ | CDK2 | P24941 | 8/20 | 0.40 |
| ▸ | CDK7 | P50613 | 8/20 | 0.40 |
| ▸ | CCNH | P51946 | 8/20 | 0.40 |
| ▸ | MNAT1 | P51948 | 8/20 | 0.40 |
| ▸ | EGFR | P00533 | 3/20 | 0.40 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25221073 | 1.00 | CDK12 (0.53) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL30533943 | 0.92 | CCNK (0.51) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL25223841 | 0.92 | CCNK (0.51) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL30533789 | 0.91 | CDK12 (0.56) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL25268914 | 0.91 | CDK12 (0.56) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL25674634 | 0.85 | CDK12 (0.58) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL25220788 | 0.83 | CCNK (0.47) | CDK12CCNKCDK13CCNA2CDK2 | |
| SCHEMBL30533842 | 0.82 | CCNK (0.43) | CDK12CCNKCCNA2CDK2CDK7 | |
| SCHEMBL25220111 | 0.82 | CCNK (0.43) | CDK12CCNKCCNA2CDK2CDK7 | |
| SCHEMBL25218676 | 0.82 | CDK12 (0.58) | CDK12CCNKCDK13CCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | claimed |
| WO-2023102184-A1 | BICYCLIC AMINE COMPOUNDS AS CDK12 INHIBITORS | INCYTE CORPORATION (US) | 2023-06-08 | — | — | WO | disclosed |