Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 4/20 | 0.40 |
| ▸ | EGFR | P00533 | 1/20 | 0.40 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.40 |
| ▸ | CRYZ | Q08257 | 1/20 | 0.40 |
| ▸ | VAT1 | Q99536 | 1/20 | 0.40 |
| ▸ | RTN4 | Q9NQC3 | 1/20 | 0.40 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | RAB9A | P51151 | 1/20 | 0.38 |
| ▸ | HTR5A | P47898 | 1/20 | 0.35 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.35 |
| ▸ | WEE1 | P30291 | 1/20 | 0.35 |
| ▸ | CTSA | P10619 | 2/20 | 0.35 |
| ▸ | HSP90AA1 | P07900 | 3/20 | 0.35 |
| ▸ | HSP90AB1 | P08238 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.35 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.35 |
| ▸ | HTR1A | P08908 | 1/20 | 0.34 |
| ▸ | ADRA1D | P25100 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24459896 | 1.00 | KRAS (0.40) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL29697501 | 0.86 | MAPK14 (0.40) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL24459895 | 0.86 | MAPK14 (0.40) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18128619 | 0.84 | KRAS (0.44) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18128427 | 0.81 | EGFR (0.41) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18128526 | 0.79 | NQO2 (0.36) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18395037 | 0.77 | PARP1 (0.47) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL20373555 | 0.76 | F2RL3 (0.39) | KRASEGFRHMOX2CRYZVAT1 | |
| SCHEMBL18128418 | 0.76 | NQO2 (0.37) | HSP90AA1HSP90AB1KDM4EMAP4K1 | |
| SCHEMBL30253478 | 0.76 | NQO2 (0.37) | HSP90AA1HSP90AB1KDM4EMAP4K1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-116745264-A | Methods and compositions for KRAS modification | 2692372安大略公司 | 2023-09-12 | — | — | CN | disclosed |