Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNE1 | P24864 | 19/20 | 0.52 |
| ▸ | CDK2 | P24941 | 19/20 | 0.52 |
| ▸ | CCND1 | P24385 | 14/20 | 0.49 |
| ▸ | CDK6 | Q00534 | 14/20 | 0.49 |
| ▸ | CDK1 | P06493 | 12/20 | 0.49 |
| ▸ | CCNB1 | P14635 | 12/20 | 0.49 |
| ▸ | CDK4 | P11802 | 11/20 | 0.49 |
| ▸ | CCND3 | P30281 | 11/20 | 0.49 |
| ▸ | CCNT1 | O60563 | 5/20 | 0.49 |
| ▸ | CDK7 | P50613 | 5/20 | 0.49 |
| ▸ | CDK9 | P50750 | 5/20 | 0.49 |
| ▸ | CCNH | P51946 | 5/20 | 0.49 |
| ▸ | MNAT1 | P51948 | 5/20 | 0.49 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25403192 | 1.00 | CCNE1 (0.52) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL25402390 | 0.92 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL30537182 | 0.92 | CCNE1 (0.56) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL30537277 | 0.87 | CCNE1 (0.67) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL25404136 | 0.87 | CCNE1 (0.67) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL25398838 | 0.86 | CCNE1 (0.59) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL30537275 | 0.86 | CCNE1 (0.59) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL25400877 | 0.85 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL30537178 | 0.85 | CCNE1 (0.53) | CCNE1CDK2CCND1CDK6CDK1 | |
| SCHEMBL25401381 | 0.85 | CCNE1 (0.54) | CCNE1CDK2CCND1CDK6CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023172957-A1 | THAIZOLE-PYRIMDIINE CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2023-09-14 | — | — | WO | claimed |
| WO-2023172957-A1 | THAIZOLE-PYRIMDIINE CDK INHIBITORS AND THEIR USE AS PHARMACEUTICALS | PRELUDE THERAPEUTICS, INCORPORATED (US) | 2023-09-14 | — | — | WO | disclosed |