Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Azd1981. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGDR2 known ✓ | Q9Y5Y4 | 20/20 | 1.00 |
| ▸ | AKR1B1 | P15121 | 8/20 | 1.00 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.75 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Azd1981 SCHEMBL1053662 | 1.00 | PTGDR2 (1.00) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL13206681 | 0.93 | PTGDR2 (0.86) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL18457198 | 0.92 | PTGDR2 (0.85) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1251735 | 0.90 | PTGDR2 (0.81) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL3293961 | 0.90 | PTGDR2 (0.81) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL2549756 | 0.89 | PTGDR2 (0.80) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1252370 | 0.89 | PTGDR2 (0.80) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1252345 | 0.88 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL904388 | 0.88 | PTGDR2 (0.79) | PTGDR2AKR1B1CYP2C9SLC6A4 | |
| SCHEMBL1251032 | 0.88 | PTGDR2 (0.78) | PTGDR2AKR1B1CYP2C9SLC6A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110483492-B | Dipeptidyl peptidase I inhibitors | 阿斯利康(瑞典)有限公司 | 2023-07-21 | — | — | CN | disclosed |