Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GAA | P10253 | 2/20 | 0.50 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 5/20 | 0.46 |
| ▸ | BRAF | P15056 | 5/20 | 0.46 |
| ▸ | KIT | P10721 | 3/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | TSHR | P16473 | 1/20 | 0.43 |
| ▸ | CASP1 | P29466 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.42 |
| ▸ | RAF1 | P04049 | 2/20 | 0.42 |
| ▸ | KCNK3 | O14649 | 1/20 | 0.42 |
| ▸ | ESYT2 | A0FGR8 | 1/20 | 0.42 |
| ▸ | PLEKHG3 | A1L390 | 1/20 | 0.42 |
| ▸ | NBAS | A2RRP1 | 1/20 | 0.42 |
| ▸ | CNOT1 | A5YKK6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3054046 | 0.86 | PTGS1 (0.47) | PTGS1CSF1RBRAFKITLMNA | |
| SCHEMBL1499372 | 0.86 | LCK (0.54) | CSF1RBRAFKITLMNATSHR | |
| SCHEMBL1499286 | 0.85 | BRAF (0.54) | CSF1RBRAFKITRAF1ABL1 | |
| SCHEMBL1499307 | 0.85 | FGFR1 (0.48) | CSF1RBRAFKITTSHRRAF1 | |
| SCHEMBL1499387 | 0.77 | NTRK1 (0.50) | CSF1RKITLMNATRPV1ROCK2 | |
| SCHEMBL13097211 | 0.77 | BRAF (0.54) | PTGS1CSF1RBRAFKITLMNA | |
| SCHEMBL1499154 | 0.76 | LCK (0.51) | CSF1RKITROCK2ABL1EGFR | |
| SCHEMBL1499144 | 0.76 | NTRK1 (0.51) | CSF1RBRAFKITLMNATRPV1 | |
| SCHEMBL13096655 | 0.74 | DDR2 (0.52) | CSF1RBRAFKITRAF1ABL1 | |
| SCHEMBL13097210 | 0.74 | BRAF (0.59) | CSF1RBRAFKITRAF1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100261730-A1 | ALKYNYLARYL COMPOUNDS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | BAYER SCHERING PHARMA AKTIENGESELLSCHAFT (DE) | 2010-10-14 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100261730-A1 | ALKYNYLARYL COMPOUNDS AND SALTS THEREOF, PHARMACEUTICAL COMPOSITIONS COMPRISING SAME, METHODS OF PREPARING SAME AND USES OF SAME | ALK, ALKBH3, EDNRB | GAA 705/4885PTGS1 668/4885ALDH1A1 321/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.