Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TLR9 | Q9NR96 | 6/20 | 0.38 |
| ▸ | TLR7 | Q9NYK1 | 5/20 | 0.38 |
| ▸ | TLR8 | Q9NR97 | 5/20 | 0.38 |
| ▸ | MAP4K1 | Q92918 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 4/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | SMPD3 | Q9NY59 | 1/20 | 0.35 |
| ▸ | USP2 | O75604 | 1/20 | 0.34 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.34 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.34 |
| ▸ | CASP1 | P29466 | 1/20 | 0.34 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | HTR7 | P34969 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 3/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25366449 | 1.00 | TLR9 (0.38) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL25365431 | 0.93 | TLR9 (0.37) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL30541634 | 0.93 | TLR9 (0.37) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL30541587 | 0.90 | TLR9 (0.42) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL25365416 | 0.90 | TLR9 (0.42) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL25363993 | 0.89 | MAP4K1 (0.40) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL30541621 | 0.89 | MAP4K1 (0.40) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL25364535 | 0.89 | TLR9 (0.39) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL30541602 | 0.89 | TLR9 (0.39) | TLR9TLR7TLR8MAP4K1MAPT | |
| SCHEMBL25365853 | 0.88 | MAP4K1 (0.36) | TLR9TLR7TLR8MAP4K1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479407-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2024-12-25 | — | — | EP | disclosed |
| WO-2023159153-A1 | SUBSTITUTED BICYCLIC HETEROARYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |