Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LRRK2 | Q5S007 | 4/20 | 0.53 |
| ▸ | CDK2 | P24941 | 3/20 | 0.50 |
| ▸ | CDK9 | P50750 | 2/20 | 0.50 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.50 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.50 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.50 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.50 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.50 |
| ▸ | TBK1 | Q9UHD2 | 5/20 | 0.43 |
| ▸ | AXL | P30530 | 2/20 | 0.43 |
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.43 |
| ▸ | CDK1 | P06493 | 2/20 | 0.43 |
| ▸ | CDC7 | O00311 | 2/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 2/20 | 0.43 |
| ▸ | PIM1 | P11309 | 2/20 | 0.43 |
| ▸ | PRKACA | P17612 | 2/20 | 0.43 |
| ▸ | GSK3B | P49841 | 2/20 | 0.43 |
| ▸ | HIPK2 | Q9H2X6 | 2/20 | 0.43 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2692195 | 1.00 | LRRK2 (0.53) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL20846296 | 0.81 | CDK2 (0.49) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL23883560 | 0.78 | LRRK2 (0.59) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL16785960 | 0.77 | LRRK2 (0.62) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL16108927 | 0.74 | CHEK1 (0.56) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL2692680 | 0.73 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL29544023 | 0.73 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL1045493 | 0.73 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL2237935 | 0.73 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 | |
| SCHEMBL30668735 | 0.73 | LRRK2 (0.57) | LRRK2CDK2CDK9CDK5CCNT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4214199-A1 | CASEIN KINASE 1 DELTA MODULATORS | JANSSEN Pharmaceutica NV (BE) | 2023-07-26 | — | — | EP | disclosed |