SCHEMBL30543746

SCHEMBL30543746

Cc1cc(C[C@@H](NC(=O)N2CCC(N3Cc4cccc(F)c4NC3=O)CC2)C(=O)N2CCC(N3CCCCC3)CC2)cc2cn[nH]c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
CALCRL Q16602 10/20 1.00
CYP3A4 P08684 6/20 1.00
CYP2D6 P10635 1/20 1.00
CALCA P06881 9/20 0.72

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL3599533 1.00 CALCRL (1.00) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL30231971 0.92 CALCRL (0.86) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL5456743 0.92 CALCRL (0.86) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL5461651 0.91 CALCRL (0.84) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL30231451 0.91 CALCRL (0.84) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL3598277 0.90 CALCRL (0.82) CALCRLCYP3A4CYP2D6
SCHEMBL30231303 0.90 CALCRL (0.82) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL3597024 0.90 CALCRL (0.82) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL3598611 0.90 CALCRL (0.82) CALCRLCYP3A4CYP2D6CALCA
SCHEMBL13053544 0.90 CALCRL (1.00) CALCRLCYP3A4CYP2D6CALCA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2023146866-A2 METHODS FOR TREATING CALCITONIN GENE-RELATED PEPTIDE (CGRP) - EXPRESSING CANCERS THE BOARD OF REGENTS OF THE UNIVERSITY OF OKLAHOMA (US) 2023-08-03 WO disclosed