SCHEMBL30543772

SCHEMBL30543772

O=C(OC[C@H](O)CN1CCc2ccccc2C1)N1CC[C@@H](c2ccccc2)C1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 1.00
WDR77 Q9BQA1 20/20 1.00

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL22545803 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545813 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545814 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL30543757 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545809 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545721 1.00 PRMT5 (1.00) PRMT5WDR77
SCHEMBL30543876 0.95 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545735 0.95 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545836 0.88 PRMT5 (1.00) PRMT5WDR77
SCHEMBL22545714 0.88 PRMT5 (1.00) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3596061-B1 COMPOUNDS USEFUL IN THE TREATMENT OR PREVENTION OF A PRMT5-MEDIATED DISORDER ARGONAUT THERAPEUTICS LTD (GB) 2023-09-06 EP disclosed