SCHEMBL30551102

SCHEMBL30551102

C[C@H]1CC[C@H](c2ccc3scnc3c2)N(C(=O)C(=O)Nc2cnc(N)c3cn[nH]c23)C1

nearest known ligand 0.68

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
PRMT5 O14744 20/20 0.68
WDR77 Q9BQA1 3/20 0.68

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25322350 1.00 PRMT5 (0.68) PRMT5WDR77
SCHEMBL25322743 0.94 PRMT5 (0.68) PRMT5WDR77
SCHEMBL25916832 0.94 PRMT5 (0.68) PRMT5WDR77
SCHEMBL25319964 0.90 PRMT5 (0.59) PRMT5WDR77
SCHEMBL30551426 0.90 PRMT5 (0.59) PRMT5WDR77
SCHEMBL30551531 0.90 PRMT5 (0.59) PRMT5WDR77
SCHEMBL25323323 0.89 PRMT5 (0.66) PRMT5WDR77
SCHEMBL30551487 0.89 PRMT5 (0.66) PRMT5WDR77
SCHEMBL25323331 0.89 PRMT5 (0.66) PRMT5WDR77
SCHEMBL25905748 0.89 PRMT5 (0.68) PRMT5WDR77

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4469455-A1 COMPOUNDS AND METHODS OF USE Tango Therapeutics, Inc. (US) 2024-12-04 EP disclosed
CN-119060035-A Nitrogen-containing polycyclic derivative inhibitor, preparation method and application thereof 上海翰森生物医药科技有限公司 2024-12-03 CN disclosed
WO-2023146990-A1 COMPOUNDS AND METHODS OF USE TANGO THERAPEUTICS, INC. (US) 2023-08-03 WO disclosed