Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTOR | P42345 | 3/20 | 0.39 |
| ▸ | RPTOR | Q8N122 | 3/20 | 0.39 |
| ▸ | MLST8 | Q9BVC4 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 2/20 | 0.35 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.35 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.35 |
| ▸ | MET | P08581 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.35 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.35 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.35 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.35 |
| ▸ | RET | P07949 | 5/20 | 0.34 |
| ▸ | KIF5B | P33176 | 5/20 | 0.34 |
| ▸ | KDR | P35968 | 5/20 | 0.34 |
| ▸ | ETV6 | P41212 | 5/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31398 | 0.83 | CHEK1 (0.33) | HPGDKDM4ENPC1ALDH1A1TP53 | |
| Bicarbonate SCHEMBL17836460 | 0.81 | MTOR (0.41) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL14298307 | 0.79 | MTOR (0.48) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL14298317 | 0.79 | MTOR (0.48) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL17850063 | 0.79 | MTOR (0.39) | MTORRPTORMLST8LMNAFLT3 | |
| SCHEMBL14246581 | 0.78 | MTOR (0.52) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL14246582 | 0.78 | MTOR (0.52) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL12461460 | 0.78 | MTOR (0.52) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL2147035 | 0.78 | MTOR (0.52) | MTORRPTORMLST8FLT3ALK | |
| SCHEMBL2147029 | 0.78 | MTOR (0.52) | MTORRPTORMLST8FLT3ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2608669-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | Merck Sharp & Dohme Corp. (US) | 2013-07-03 | — | — | EP | claimed |
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | claimed |