Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 9/20 | 0.64 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.64 |
| ▸ | NAMPT | P43490 | 2/20 | 0.50 |
| ▸ | CNR2 | P34972 | 1/20 | 0.48 |
| ▸ | ROCK2 | O75116 | 4/20 | 0.48 |
| ▸ | GRK2 | P25098 | 3/20 | 0.48 |
| ▸ | PRKCA | P17252 | 2/20 | 0.48 |
| ▸ | GRK3 | P35626 | 2/20 | 0.48 |
| ▸ | GRK7 | Q8WTQ7 | 2/20 | 0.48 |
| ▸ | ITK | Q08881 | 1/20 | 0.48 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.47 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.47 |
| ▸ | PRKCG | P05129 | 1/20 | 0.47 |
| ▸ | PRKACA | P17612 | 1/20 | 0.47 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.47 |
| ▸ | GSK3A | P49840 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | PRKX | P51817 | 1/20 | 0.47 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20931373 | 1.00 | MAPK1 (0.64) | MAPK1MAPK3NAMPTCNR2ROCK2 | |
| SCHEMBL20931672 | 0.91 | MAPK1 (0.55) | MAPK1MAPK3NAMPTROCK2GRK2 | |
| SCHEMBL20931576 | 0.90 | MAPK1 (0.66) | MAPK1MAPK3ROCK2GRK2 | |
| SCHEMBL20931729 | 0.86 | MAPK1 (0.49) | MAPK1MAPK3 | |
| SCHEMBL20916803 | 0.85 | MAPK1 (0.52) | MAPK1MAPK3 | |
| SCHEMBL20931859 | 0.85 | MAPK1 (0.47) | MAPK1MAPK3NAMPTROCK2GRK2 | |
| SCHEMBL20916861 | 0.84 | MAPK1 (0.48) | MAPK1MAPK3NAMPTROCK2GRK2 | |
| SCHEMBL20917257 | 0.84 | MAPK1 (0.48) | MAPK1MAPK3NAMPTDYRK1A | |
| SCHEMBL20931411 | 0.84 | MAPK1 (0.50) | MAPK1MAPK3ROCK2PRKACAROCK1 | |
| SCHEMBL30554297 | 0.84 | MAPK1 (0.50) | MAPK1MAPK3ROCK2PRKACAROCK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112020357-B | Salt of indazolyl-containing tricyclic derivative and crystal form thereof | 上海翰森生物医药科技有限公司 | 2023-08-29 | — | — | CN | disclosed |