Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 | P25103 | 3/20 | 0.38 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.36 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | HTRA1 | Q92743 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.34 |
| ▸ | SETD7 | Q8WTS6 | 2/20 | 0.34 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.34 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.34 |
| ▸ | RORC | P51449 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23126416 | 1.00 | TACR1 (0.38) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL21831298 | 0.90 | TACR1 (0.39) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL29922666 | 0.89 | TACR1 (0.36) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL29923023 | 0.89 | TACR1 (0.36) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL30554486 | 0.88 | TACR1 (0.37) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL21910374 | 0.88 | TACR1 (0.37) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL25138125 | 0.88 | TACR1 (0.40) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL29922480 | 0.86 | MAPK14 (0.44) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL29922715 | 0.86 | MAPK14 (0.44) | TACR1HDAC1HDAC2GPR119MEN1 | |
| SCHEMBL30554491 | 0.86 | MAPK14 (0.44) | TACR1HDAC1HDAC2GPR119MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3814348-B9 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-11-01 | — | — | EP | disclosed |
| EP-3814348-B1 | SUBSTITUTED NAPHTHYRIDINONE COMPOUNDS USEFUL AS T CELL ACTIVATORS | BRISTOL MYERS SQUIBB CO (US) | 2023-08-02 | — | — | EP | disclosed |