Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 10/20 | 0.41 |
| ▸ | KCNH2 | Q12809 | 9/20 | 0.41 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.38 |
| ▸ | MTOR | P42345 | 1/20 | 0.38 |
| ▸ | KDM2B | Q8NHM5 | 4/20 | 0.37 |
| ▸ | JAK2 | O60674 | 1/20 | 0.36 |
| ▸ | JAK3 | P52333 | 1/20 | 0.36 |
| ▸ | PTK2 | Q05397 | 1/20 | 0.36 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.36 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.36 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25364915 | 1.00 | HRH3 (0.41) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL25366803 | 0.92 | TLR9 (0.40) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL30557403 | 0.91 | PIK3CD (0.37) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL25364884 | 0.91 | PIK3CD (0.37) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL30557426 | 0.91 | PIK3CD (0.38) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL25364620 | 0.91 | PIK3CD (0.38) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL30557476 | 0.89 | PIK3CD (0.39) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL25365785 | 0.89 | PIK3CD (0.39) | HRH3KCNH2ADRA1APIK3CDPIK3CA | |
| SCHEMBL25365560 | 0.89 | TLR9 (0.45) | PIK3CDPIK3CAMTORJAK2JAK3 | |
| SCHEMBL30557511 | 0.89 | TLR9 (0.45) | PIK3CDPIK3CAMTORJAK2JAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4479135-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2024-12-25 | — | — | EP | claimed |
| CN-118786130-A | Substituted imidazopyridinyl compounds useful as TLR9 inhibitors | 百时美施贵宝公司 | 2024-10-15 | — | — | CN | claimed |
| WO-2023159154-A9 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-10-10 | — | — | WO | claimed |
| WO-2023159154-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | claimed |
| EP-4479135-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | Bristol-Myers Squibb Company (US) | 2024-12-25 | — | — | EP | disclosed |
| CN-118786130-A | Substituted imidazopyridinyl compounds useful as TLR9 inhibitors | 百时美施贵宝公司 | 2024-10-15 | — | — | CN | disclosed |
| WO-2023159154-A9 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2024-10-10 | — | — | WO | disclosed |
| WO-2023159154-A1 | SUBSTITUTED IMIDAZOPYRIDINYL COMPOUNDS USEFUL AS INHIBITORS OF TLR9 | BRISTOL-MYERS SQUIBB COMPANY (US) | 2023-08-24 | — | — | WO | disclosed |