Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 5/20 | 0.51 |
| ▸ | NPC1 | O15118 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 3/20 | 0.48 |
| ▸ | PCSK9 | Q8NBP7 | 4/20 | 0.47 |
| ▸ | MAP1LC3B | Q9GZQ8 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.46 |
| ▸ | KCNA5 | P22460 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | TP53 | P04637 | 2/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.43 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | HPGDS | O60760 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23240039 | 0.87 | PCSK9 (0.57) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL23239863 | 0.87 | PCSK9 (0.57) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL19996145 | 0.83 | PCSK9 (0.58) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL19995857 | 0.83 | PCSK9 (0.58) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL23240040 | 0.83 | PCSK9 (0.53) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL20001122 | 0.82 | PCSK9 (0.51) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL30228593 | 0.82 | PCSK9 (0.51) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL22687381 | 0.82 | PCSK9 (0.51) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL22697379 | 0.81 | PCSK9 (0.49) | RAB9ANPC1PKMALDH1A1LMNA | |
| SCHEMBL22687410 | 0.81 | PCSK9 (0.49) | RAB9ANPC1PKMALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023165373-A1 | MICROMOLECULAR PCSK9 PROTEIN DEGRADATION AGENT, PREPARATION METHOD THEREFOR, AND USE THEREOF | 复旦大学 | 2023-09-07 | — | — | WO | disclosed |