Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | ENPP1 | P22413 | 5/20 | 0.48 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 2/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 4/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.40 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | IRAK1 | P51617 | 1/20 | 0.40 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.40 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.40 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21664258 | 1.00 | HTT (0.50) | HTTENPP1CHRM4DYRK1APDGFRB | |
| SCHEMBL21664250 | 0.94 | HTT (0.52) | HTTENPP1CHRM4PDGFRBLMNA | |
| SCHEMBL30562933 | 0.94 | HTT (0.52) | HTTENPP1CHRM4PDGFRBLMNA | |
| SCHEMBL21664254 | 0.92 | ENPP1 (0.48) | HTTENPP1PRKDCIRAK1PIK3CD | |
| SCHEMBL21664238 | 0.89 | HTT (0.47) | HTTENPP1CHRM4DYRK1APDGFRB | |
| SCHEMBL30562887 | 0.89 | HTT (0.47) | HTTENPP1CHRM4DYRK1APDGFRB | |
| SCHEMBL25551755 | 0.89 | ENPP1 (0.49) | ENPP1CHRM4DYRK1APDGFRBPRKDC | |
| SCHEMBL24064742 | 0.88 | SLC22A12 (0.50) | HTTENPP1CHRM4CNR1CNR2 | |
| SCHEMBL21664244 | 0.88 | ENPP1 (0.48) | ENPP1DYRK1APDGFRBPRKDCLMNA | |
| SCHEMBL21664403 | 0.88 | HTT (0.50) | HTTENPP1DYRK1APDGFRBPRKDC |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3551188-B1 | SUBSTITUTED QUINAZOLINE SULFONAMIDES AS THIOREDOXIN INTERACTING PROTEIN (TXNIP) INHIBITORS | SOUTHERN RES INST (US) | 2023-10-18 | — | — | EP | disclosed |