Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 2/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.39 |
| ▸ | MDM4 | O15151 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | BACE1 | P56817 | 1/20 | 0.37 |
| ▸ | TLR2 | O60603 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25384740 | 0.90 | PTPN1 (0.46) | MDM2PTPN1MDM4TP53TLR2 | |
| SCHEMBL25384735 | 0.90 | PTPN1 (0.46) | MDM2PTPN1MDM4TP53TLR2 | |
| SCHEMBL29363204 | 0.83 | MDM2 (0.44) | MDM2PTPN1MDM4TP53BACE1 | |
| SCHEMBL21175067 | 0.81 | MDM2 (0.52) | MDM2PTPN1MDM4TP53BACE1 | |
| SCHEMBL21175068 | 0.81 | MDM2 (0.52) | MDM2PTPN1MDM4TP53BACE1 | |
| SCHEMBL16093056 | 0.80 | MDM2 (0.48) | MDM2PTPN1MDM4TP53TLR2 | |
| SCHEMBL10078351 | 0.80 | MDM2 (0.48) | MDM2PTPN1MDM4TP53TLR2 | |
| SCHEMBL27728772 | 0.79 | MDM4 (0.49) | MDM2MDM4TP53TLR2 | |
| SCHEMBL27009319 | 0.79 | PTPN1 (0.47) | MDM2PTPN1MDM4TP53 | |
| SCHEMBL23728660 | 0.79 | MDM2 (0.53) | MDM2PTPN1MDM4TP53TLR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4490142-A2 | PCNA INHIBITORS AND USES THEREOF | City of Hope (US) | 2025-01-15 | — | — | EP | disclosed |
| WO-2023172880-A2 | PCNA INHIBITORS AND USES THEREOF | CITY OF HOPE (US) | 2023-09-14 | — | — | WO | disclosed |