Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.45 |
| ▸ | USP2 | O75604 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | LMNA | P02545 | 3/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | PSEN1 | P49768 | 1/20 | 0.43 |
| ▸ | PSEN2 | P49810 | 1/20 | 0.43 |
| ▸ | APH1B | Q8WW43 | 1/20 | 0.43 |
| ▸ | NCSTN | Q92542 | 1/20 | 0.43 |
| ▸ | APH1A | Q96BI3 | 1/20 | 0.43 |
| ▸ | PSENEN | Q9NZ42 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.42 |
| ▸ | STS | P08842 | 2/20 | 0.42 |
| ▸ | FAAH | O00519 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21381749 | 1.00 | MEN1 (0.48) | MEN1KMT2ANPSR1USP2HPGD | |
| SCHEMBL18741911 | 0.90 | MEN1 (0.52) | MEN1KMT2ANPSR1USP2HPGD | |
| SCHEMBL30294196 | 0.90 | MEN1 (0.52) | MEN1KMT2ANPSR1USP2HPGD | |
| SCHEMBL941380 | 0.87 | MEN1 (0.56) | MEN1KMT2ANPSR1USP2HPGD | |
| SCHEMBL14851551 | 0.85 | KDM4E (0.46) | KMT2AKDM4ELMNATP53HPGDS | |
| SCHEMBL25254039 | 0.85 | RET (0.43) | MEN1KMT2ANPSR1USP2HPGD | |
| SCHEMBL29497024 | 0.85 | RET (0.43) | MEN1KMT2ANPSR1USP2HPGD | |
| SCHEMBL17729512 | 0.84 | ALOX5AP (0.45) | KDM4EUSP30HPGDSALOX5APFEN1 | |
| SCHEMBL23264041 | 0.84 | KDM4E (0.45) | KDM4EUSP30HPGDSALOX5APFEN1 | |
| SCHEMBL20743115 | 0.84 | ALOX5AP (0.45) | KDM4EPOLBSMN1; SMN2HPGDSALOX5AP |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111936503-B | Oxazine monoacylglycerol lipase (MAGL) inhibitors | 豪夫迈·罗氏有限公司 | 2023-09-12 | — | — | CN | disclosed |