Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNJ1 | P48048 | 17/20 | 0.77 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19475704 | 1.00 | KCNJ1 (0.77) | KCNJ1KCNH2TP53LMNAMAPT | |
| SCHEMBL30569197 | 0.90 | KCNJ1 (0.66) | KCNJ1KCNH2TP53LMNAMAPT | |
| SCHEMBL19513183 | 0.90 | KCNJ1 (0.66) | KCNJ1KCNH2TP53LMNAMAPT | |
| SCHEMBL19475687 | 0.87 | KCNJ1 (1.00) | KCNJ1KCNH2 | |
| SCHEMBL30569180 | 0.87 | KCNJ1 (1.00) | KCNJ1KCNH2 | |
| SCHEMBL19475688 | 0.86 | KCNJ1 (0.62) | KCNJ1KCNH2TP53LMNAMAPT | |
| SCHEMBL30569205 | 0.86 | KCNJ1 (0.62) | KCNJ1KCNH2TP53LMNAMAPT | |
| SCHEMBL30569203 | 0.84 | KCNJ1 (0.78) | KCNJ1KCNH2 | |
| SCHEMBL19475753 | 0.84 | KCNJ1 (0.78) | KCNJ1KCNH2 | |
| SCHEMBL19475747 | 0.82 | KCNJ1 (0.64) | KCNJ1KCNH2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3445762-B1 | SUBSTITUTED BICYCLIC HETEROCYCLIC COMPOUNDS | BRISTOL MYERS SQUIBB CO (US) | 2023-09-13 | — | — | EP | disclosed |