Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | COMT | P21964 | 11/20 | 0.70 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.68 |
| ▸ | FTO | Q9C0B1 | 2/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17962279 | 1.00 | COMT (0.70) | COMTKDM4EFTO | |
| SCHEMBL17962376 | 0.87 | COMT (0.70) | COMTKDM4EFTO | |
| SCHEMBL17960049 | 0.82 | COMT (1.00) | COMTKDM4EFTO | |
| SCHEMBL17962271 | 0.81 | KDM4E (1.00) | COMTKDM4EFTO | |
| SCHEMBL17962389 | 0.80 | COMT (0.71) | COMTKDM4EFTO | |
| SCHEMBL17962355 | 0.79 | COMT (0.72) | COMTKDM4EFTO | |
| SCHEMBL17962258 | 0.79 | COMT (0.78) | COMTKDM4EFTO | |
| SCHEMBL17962417 | 0.79 | COMT (0.78) | COMTKDM4EFTO | |
| SCHEMBL17962356 | 0.78 | COMT (0.73) | COMTKDM4EFTO | |
| SCHEMBL17962293 | 0.77 | COMT (0.69) | COMTKDM4EFTO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3250209-B1 | COMT INHIBITING METHODS AND COMPOSITIONS | LIEBER INST FOR BRAIN DEVELOPMENT (US) | 2023-09-13 | — | — | EP | disclosed |