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SCHEMBL30577977

SCHEMBL30577977

CC[C@H](C)[C@H](NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CC(=O)O)NC(=O)[C@H](CS)NC(=O)[C@H](C)NC(=O)[C@H](CO)NC(=O)[C@@H](N)CO)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCNC(=N)N)C(=O)N[C@@H](CO)C(=O)N[C@@H](CS)C(=O)N[C@@H](Cc1c[nH]cn1)C(=O)O

nearest known ligand 0.56

Predicted protein targets (top 4)

geneUniProtsupporting neighboursconfidence
▸ GLP1R P43220 17/20 0.56
▸ CXCR4 P61073 1/20 0.55
▸ PTH1R Q03431 1/20 0.53
▸ KEAP1 Q14145 1/20 0.52

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29965711 0.92 CXCR4 (0.56) GLP1RCXCR4
SCHEMBL30648469 0.92 GLP1R (0.68) GLP1R
SCHEMBL30080640 0.90 C5AR1 (0.57) —
SCHEMBL31399727 0.89 CXCR4 (0.53) GLP1RCXCR4
SCHEMBL31031499 0.88 GLP1R (0.57) GLP1RKEAP1
SCHEMBL31000922 0.87 GLP1R (0.64) GLP1R
SCHEMBL31278659 0.87 IL23R (0.52) CXCR4
SCHEMBL29883587 0.87 IL23R (0.61) GLP1R
SCHEMBL29613381 0.87 GLP1R (0.61) GLP1R
SCHEMBL31399734 0.86 IL23R (0.51) GLP1RCXCR4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250114429-A1 VISTA ANTAGONIST AND METHODS OF USE KING S COLLEGE LONDON (GB) 2025-04-10 — — US claimed
US-12064463-B2 Vista antagonist and methods of use KING'S COLLEGE LONDON (GB) 2024-08-20 — — US claimed
US-11752189-B2 Vista antagonist and methods of use THE TRUSTEES OF DARTMOUTH COLLEGE (US) 2023-09-12 — — US claimed
US-20250114429-A1 VISTA ANTAGONIST AND METHODS OF USE KING S COLLEGE LONDON (GB) 2025-04-10 — — US disclosed
US-12064463-B2 Vista antagonist and methods of use KING'S COLLEGE LONDON (GB) 2024-08-20 — — US disclosed
US-20240158507-A1 VISTA Antagonist and Methods of Use DARTMOUTH COLLEGE (US) 2024-05-16 — — US disclosed
US-11752189-B2 Vista antagonist and methods of use THE TRUSTEES OF DARTMOUTH COLLEGE (US) 2023-09-12 — — US disclosed
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