Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTPN1 | P18031 | 4/20 | 0.46 |
| ▸ | ACE | P12821 | 2/20 | 0.46 |
| ▸ | HDAC8 | Q9BY41 | 7/20 | 0.44 |
| ▸ | TACR1 | P25103 | 1/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.42 |
| ▸ | NAMPT | P43490 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30582004 | 0.90 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL6585678 | 0.88 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL30581791 | 0.85 | PTPN1 (0.46) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL30167025 | 0.84 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL3550883 | 0.84 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL24172862 | 0.84 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL3550881 | 0.84 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL30167036 | 0.84 | PTPN1 (0.47) | PTPN1ACEHDAC8TACR1F10 | |
| SCHEMBL25377304 | 0.84 | ACE (0.50) | ACETACR1F10 | |
| SCHEMBL30581966 | 0.82 | HDAC8 (0.45) | PTPN1ACEHDAC8TACR1F10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4482832-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | Les Laboratoires Servier (FR) | 2025-01-01 | — | — | EP | disclosed |
| CN-119053587-A | 5- [7- (3, 4-Dihydro-1H-isoquinoline-2-carbonyl) -1,2,3,4 tetrahydroisoquinolin-6-yl ] -1H-pyrrole-3-carboxamide derivatives, pharmaceutical compositions containing same and use thereof as pro-apoptotic agents | 法国施维雅药厂 | 2024-11-29 | — | — | CN | disclosed |
| WO-2023161317-A1 | 5-[7-(3,4-DIHYDRO-1H-ISOQUINOLINE-2-CARBONYL)-1,2,3,4 TETRAHYDROISOQUINOLIN-6-Y L]-1H-PYRROLE-3-CARBOXAMIDE DERIVATIVES, PHARMACEUTICAL COMPOSITIONS CONTAINING THEM AND THEIR USES AS PRO-APOPTOTIC AGENTS | LES LABORATOIRES SERVIER (FR) | 2023-08-31 | — | — | WO | disclosed |