Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR4 | P51679 | 19/20 | 0.69 |
| ▸ | CCR5 | P51681 | 1/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.45 |
| ▸ | SLCO1B1 | Q9Y6L6 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30260 | 0.88 | CCR4 (0.70) | CCR4CCR5FFAR4SLCO1B1KDM4E | |
| SCHEMBL30133 | 0.83 | CCR4 (0.66) | CCR4CCR5FFAR4SLCO1B1KDM4E | |
| SCHEMBL30786 | 0.82 | CCR4 (0.52) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL31157 | 0.82 | CCR4 (0.53) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10278771 | 0.82 | CCR4 (1.00) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10278777 | 0.82 | CCR4 (1.00) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL30630 | 0.81 | CCR4 (0.76) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL30728 | 0.81 | CCR4 (0.62) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL30085 | 0.81 | CCR4 (0.67) | CCR4CCR5FFAR4SLCO1B1 | |
| SCHEMBL10279082 | 0.80 | CCR4 (0.96) | CCR4CCR5FFAR4SLCO1B1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012025473-A1 | CC.CHEMOKINE RECEPTOR 4 ANTAGONISTS | GLAXO GROUP LIMITED (GB) | 2012-03-01 | — | — | WO | disclosed |