Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SRC | P12931 | 5/20 | 0.36 |
| ▸ | EGFR | P00533 | 3/20 | 0.36 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | ABL1 | P00519 | 2/20 | 0.34 |
| ▸ | ABL2 | P42684 | 2/20 | 0.34 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.34 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.34 |
| ▸ | RET | P07949 | 3/20 | 0.33 |
| ▸ | KDR | P35968 | 3/20 | 0.33 |
| ▸ | TGFBR1 | P36897 | 1/20 | 0.33 |
| ▸ | ACACB | O00763 | 2/20 | 0.33 |
| ▸ | EIF2AK4 | Q9P2K8 | 1/20 | 0.32 |
| ▸ | USP1 | O94782 | 1/20 | 0.32 |
| ▸ | TACR1 | P25103 | 1/20 | 0.32 |
| ▸ | JAK2 | O60674 | 1/20 | 0.32 |
| ▸ | JAK1 | P23458 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26105703 | 1.00 | SRC (0.36) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL31219425 | 0.90 | SRC (0.40) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL26109440 | 0.90 | SRC (0.40) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL30582562 | 0.90 | SRC (0.40) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL30582563 | 0.89 | SRC (0.36) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL26109332 | 0.89 | SRC (0.36) | SRCEGFRMAP4K4ABL1ABL2 | |
| SCHEMBL26110909 | 0.88 | SRC (0.39) | SRCEGFRABL1ABL2RET | |
| SCHEMBL30582595 | 0.88 | SRC (0.39) | SRCEGFRABL1ABL2RET | |
| SCHEMBL26588640 | 0.87 | FGFR1 (0.41) | EGFRJAK2JAK1 | |
| SCHEMBL30582632 | 0.86 | SRC (0.37) | SRCEGFRMAP4K4ABL1ABL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4499616-A1 | SPIROBICYCLIC COMPOUNDS | Acerand Therapeutics (Hong Kong) Limited (HK) | 2025-02-05 | — | — | EP | disclosed |
| CN-119013260-A | Spirobicyclic compounds | 优领医药科技(香港)有限公司 | 2024-11-22 | — | — | CN | disclosed |
| WO-2023192502-A1 | SPIROBICYCLIC COMPOUNDS | ACERAND THERAPEUTICS (USA) LIMITED (US) | 2023-10-05 | — | — | WO | disclosed |