Styrene

Styrene

SCHEMBL3058331

C=CCOC(=O)/C=C\C(=O)O.C=Cc1ccccc1

nearest known ligand 0.53

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HCAR2 Q8TDS4 8/20 0.53
APP P05067 1/20 0.48
CYP3A4 P08684 1/20 0.47
MAPT P10636 2/20 0.45
CACNA1B Q00975 1/20 0.45
APBA1 Q02410 1/20 0.45
CASP1 P29466 1/20 0.44
LMNA P02545 2/20 0.44
KDM4E B2RXH2 1/20 0.44
MEN1 O00255 1/20 0.44
GAA P10253 1/20 0.44
MAPK1 P28482 1/20 0.44
KMT2A Q03164 1/20 0.44
ALDH1A1 P00352 2/20 0.44
TSHR P16473 2/20 0.44
HSD17B10 Q99714 1/20 0.42
HDAC3 O15379 1/20 0.42
TNKS O95271 1/20 0.42
HDAC4 P56524 1/20 0.42
HDAC1 Q13547 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Styrene SCHEMBL9551543 1.00 HCAR2 (0.53) HCAR2APPCYP3A4MAPTCACNA1B
Styrene SCHEMBL11873129 0.95 CYP3A4 (0.51) HCAR2APPCYP3A4MAPTCACNA1B
Styrene SCHEMBL11873141 0.95 CYP3A4 (0.51) HCAR2APPCYP3A4MAPTCACNA1B
Ethyl Fumarate SCHEMBL4566825 0.89 HCAR2 (0.50) HCAR2APPCYP3A4MAPTCASP1
Styrene SCHEMBL11408839 0.89 APP (0.47) HCAR2APPCYP3A4MAPTCACNA1B
Styrene SCHEMBL11408877 0.89 APP (0.47) HCAR2APPCYP3A4MAPTCACNA1B
SCHEMBL2060238 0.87 HCAR2 (0.49) HCAR2APPCYP3A4MAPTCACNA1B
Styrene SCHEMBL167641 0.85 CYP3A4 (0.51) APPCYP3A4MAPTCASP1LMNA
Ethyl Fumarate SCHEMBL8427384 0.84 HCAR2 (0.62) HCAR2MAPTLMNAMEN1KMT2A
Ethyl Fumarate SCHEMBL8427380 0.84 HCAR2 (0.62) HCAR2MAPTLMNAMEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 21 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-6818601-B1 REACTION PRODUCT OF HYDROCARBON POLYMER GRAFTED WITH ALPHA,BETA-ETHYLENICALLY UNSATURATED CARBOXYLIC ACID AND AN AMINE THE LUBRIZOL CORPORATION 2004-11-16 US claimed
EP-1551945-B1 VISCOSITY IMPROVER COMPOSITIONS PROVIDING IMPROVED LOW TEMPERATURE CHARACTERISTICS TO LUBRICATING OIL LUBRIZOL CORP (US) 2016-07-13 EP disclosed
US-8524645-B2 Viscosity improver compositions providing improved low temperature characteristics to lubricating oil THE LUBRIZOL CORPORATION (US) 2013-09-03 US disclosed
US-20100292114-A1 Viscosity Improver Compositions Providing Improved LowTemperature Characteristics to Lubricating Oil THE LUBRIZOL CORPORATION (US) 2010-11-18 US disclosed
US-7776804-B2 Viscosity improver compositions providing improved low temperature characteristics to lubricating oil THE LUBRIZOL CORPORATION (US) 2010-08-17 US disclosed
EP-1309656-B1 POLYMERIC MIXTURE USEFUL AS VISCOSITY IMPROVER FOR LUBRICATING OILS LUBRIZOL CORP (US) 2009-09-09 EP disclosed
US-7402235-B2 Viscosity improver compositions providing improved low temperature characteristics to lubricating oils THE LUBRIZOL CORPORATION (US) 2008-07-22 US disclosed
US-7238650-B2 Low-chlorine, polyolefin-substituted, with amine reacted, alpha-beta unsaturated carboxylic compounds THE LUBRIZOL CORPORATION (US) 2007-07-03 US disclosed
US-20060211586-A1 Viscosity improver compositions providing improved low temperature characteristics to lubricating oil THE LUBRIZOL CORPORATION (US) 2006-09-21 US disclosed
EP-1551945-A1 VISCOSITY IMPROVER COMPOSITIONS PROVIDING IMPROVED LOW TEMPERATURE CHARACTERISTICS TO LUBRICATING OIL The Lubrizol Corporation (US) 2005-07-13 EP disclosed
WO-2004087849-A1 VISCOSITY IMPROVER COMPOSITIONS PROVIDING IMPROVED LOW TEMPERATURE CHARACTERISTICS TO LUBRICATING OIL THE LUBRIZOL CORPORATION (US) 2004-10-14 WO disclosed
US-20040147412-A1 Low-chlorine, polyolefin-substituted, wiyh amine reacted, alpha-beta unsaturated carboxylic compounds LUBRIZOL CORPORATION, THE 2004-07-29 US disclosed
EP-1409620-A1 LOW-CHLORINE, POLYOLEFIN-SUBSTITUTED, WITH AMINE REACTED, ALPHA-BETA UNSATURATED CARBOXYLIC COMPOUNDS THE LUBRIZOL CORPORATION (US) 2004-04-21 EP disclosed
US-20040038850-A1 Viscosity improver compositions providing improved low temperature characteristics to lubricating oils LUBRIZOL CORPORATION, THE 2004-02-26 US disclosed
EP-1309656-A2 POLYMERIC MIXTURE USEFUL AS VISCOSITY IMPROVER FOR LUBRICATING OILS THE LUBRIZOL CORPORATION (US) 2003-05-14 EP disclosed
WO-2003004589-A1 LOW-CHLORINE, POLYOLEFIN-SUBSTITUTED, WITH AMINE REACTED, ALPHA-BETA UNSATURATED CARBOXYLIC COMPOUNDS THE LUBRIZOL CORPORATION (US) 2003-01-16 WO disclosed
WO-2002010276-A2 POLYMERIC MIXTURE USEFUL AS VISCOSITY IMPROVER FOR LUBRICATING OILS THE LUBRIZOL CORPORATION (US) 2002-02-07 WO disclosed
EP-0665468-B1 Staining inhibitor for photopolymerizable compositions containing a tetrazole MACDERMID IMAGING TECHNOLOGY (US) 2000-04-19 EP disclosed
EP-0665468-A1 Staining inhibitor for photopolymerizable compositions containing a tetrazole HERCULES INCORPORATED (US) 1995-08-02 EP disclosed
US-5204012-A Esterification product of an ethylene oxide-propylene oxide block copolymer with a long chain monocarboxylic acid ETHYL CORPORATION (US) 1993-04-20 US disclosed