SCHEMBL30587247

SCHEMBL30587247

COC(=O)c1nc(N2C3CCC2CN(C(=O)OC(C)(C)C)C3)c2c3c(c(-c4ccc(F)c5sc(NC(=O)OC(C)(C)C)c(C#N)c45)c(Cl)c2n1)COC3

nearest known ligand 0.30

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
MTOR P42345 1/20 0.30
BTK Q06187 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL26117616 1.00 MTOR (0.30) MTORBTK
SCHEMBL26114767 0.93 MTOR (0.31) MTOR
SCHEMBL30587221 0.93 MTOR (0.31) MTOR
SCHEMBL30587249 0.91 BTK (0.31) MTORBTK
SCHEMBL30587210 0.89 USP30 (0.31) BTK
SCHEMBL26117746 0.89 BTK (0.31) BTK
SCHEMBL26118980 0.89 USP30 (0.31) BTK
SCHEMBL30587211 0.89 USP30 (0.31) BTK
SCHEMBL30587267 0.89 BTK (0.31) BTK
SCHEMBL26119054 0.88 MEN1 (0.31)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4499233-A1 KRAS INHIBITORS Eli Lilly and Company (US) 2025-02-05 EP disclosed
CN-119095853-A KRAS inhibitors 伊莱利利公司 2024-12-06 CN disclosed
WO-2023183585-A1 KRAS INHIBITORS ELI LILLY AND COMPANY (US) 2023-09-28 WO disclosed