Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KCNA5 | P22460 | 7/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.40 |
| ▸ | RORC | P51449 | 2/20 | 0.40 |
| ▸ | MCHR1 | Q99705 | 4/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.39 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.39 |
| ▸ | RHOA | P61586 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL305907 | 1.00 | KCNA5 (0.42) | KCNA5KCNH2KDM1ARORCMCHR1 | |
| SCHEMBL3380043 | 0.98 | KCNA5 (0.43) | KCNA5KCNH2KDM1ARORCMCHR1 | |
| SCHEMBL3379291 | 0.97 | KCNA5 (0.45) | KCNA5KCNH2KDM1ARORCMCHR1 | |
| SCHEMBL3379283 | 0.97 | KCNA5 (0.45) | KCNA5KCNH2KDM1ARORCMCHR1 | |
| SCHEMBL3377427 | 0.91 | KCNA5 (0.45) | KCNA5KCNH2KDM1ARORCMEN1 | |
| SCHEMBL302683 | 0.83 | KCNA5 (0.39) | KCNA5KCNH2RORCMCHR1MEN1 | |
| SCHEMBL3377129 | 0.80 | MEN1 (0.55) | KCNA5KCNH2RORCMEN1KMT2A | |
| SCHEMBL3379276 | 0.75 | NR1H2 (0.45) | KCNA5KCNH2RORCMEN1KMT2A | |
| SCHEMBL302783 | 0.75 | SIRT2 (0.45) | KCNA5KCNH2RORCMEN1KMT2A | |
| SCHEMBL3376406 | 0.75 | SIRT2 (0.44) | KCNA5KCNH2RORCMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| JP-2012500836-A | — | — | 2012-01-12 | — | — | JP | claimed |
| EP-2342177-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | Xention Limited (GB) | 2011-07-13 | — | — | EP | claimed |
| WO-2010023448-A1 | NOVEL POTASSIUM CHANNEL BLOCKERS | XENTION LIMITED (GB) | 2010-03-04 | — | — | WO | claimed |