Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.57 |
| ▸ | SMARCA2 | P51531 | 1/20 | 0.56 |
| ▸ | SMARCA4 | P51532 | 1/20 | 0.56 |
| ▸ | PBRM1 | Q86U86 | 1/20 | 0.56 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 5/20 | 0.53 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.52 |
| ▸ | CKS1B | P61024 | 2/20 | 0.50 |
| ▸ | SKP1 | P63208 | 2/20 | 0.50 |
| ▸ | SKP2 | Q13309 | 2/20 | 0.50 |
| ▸ | DTYMK | P23919 | 1/20 | 0.49 |
| ▸ | KIT | P10721 | 2/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | ACHE | P22303 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | AKT1 | P31749 | 1/20 | 0.46 |
| ▸ | GBA1 | P04062 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14206364 | 1.00 | POLB (0.57) | POLBSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL10317314 | 0.85 | POLB (0.58) | POLBSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL22391780 | 0.85 | POLB (0.58) | POLBSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL4459331 | 0.85 | MAP4K4 (0.55) | POLBSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL21401570 | 0.84 | POLB (0.57) | POLBSMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL123592 | 0.84 | POLB (0.71) | POLBSMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL20919401 | 0.83 | POLB (0.56) | POLBSMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL30292496 | 0.83 | POLB (0.56) | POLBSMARCA2SMARCA4PBRM1GPR119 | |
| SCHEMBL29741422 | 0.83 | POLB (0.56) | POLBSMARCA2SMARCA4PBRM1MAP4K4 | |
| SCHEMBL3335222 | 0.83 | POLB (0.56) | POLBSMARCA2SMARCA4PBRM1MAP4K4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4496570-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | The Scripps Research Institute (US) | 2025-01-29 | — | — | EP | disclosed |
| WO-2023183768-A2 | SMALL MOLECULE INHIBITORS OF TEA DOMAIN FAMILY MEMBERS | THE SCRIPPS RESEARCH INSTITUTE (US) | 2023-09-28 | — | — | WO | disclosed |