Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 3/20 | 0.34 |
| ▸ | CA2 | P00918 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 2/20 | 0.34 |
| ▸ | CA9 | Q16790 | 2/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.31 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1014496 | 0.92 | — | — | |
| SCHEMBL10800821 | 0.89 | — | — | |
| SCHEMBL3413582 | 0.86 | — | — | |
| SCHEMBL4473841 | 0.86 | CA1 (0.42) | CA1CA2CA12CA9CYP2C19 | |
| SCHEMBL3415468 | 0.86 | CA1 (0.42) | CA1CA2CA12CA9CYP2C19 | |
| SCHEMBL8530196 | 0.86 | CA1 (0.42) | CA1CA2CA12CA9CYP2C19 | |
| SCHEMBL3416195 | 0.86 | CA1 (0.42) | CA1CA2CA12CA9CYP2C19 | |
| SCHEMBL3415460 | 0.86 | CA1 (0.42) | CA1CA2CA12CA9CYP2C19 | |
| Cyclohexane SCHEMBL10804991 | 0.86 | CA1 (0.42) | CA1CA2CA12CA9CYP2C19 | |
| SCHEMBL221594 | 0.86 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20080119559-A1 | Topically active agents to remove actinic keratoses and basal (BCC) and squamous (SCC) cell carcinomas using a combination of sulindac, its metabolites and derivatives with an oxidizing agent to generate reactive oxygen species nontoxic to normal cells; sulindac methionine sulfoxide/hydrogen peroxide | FLORIDA ATLANTIC UNIVERSITY (US) | 2008-05-22 | — | — | US | claimed |
| EP-1865972-A2 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS | FLORIDA ATLANTIC UNIVERSITY (US) | 2007-12-19 | — | — | EP | claimed |
| US-20060235080-A1 | Treatment or prevention of cancer and precancerous disorders | FLORIDA ATLANTIC UNIVERSITY (US) | 2006-10-19 | — | — | US | claimed |
| WO-2006102439-A2 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS | FLORIDA ATLANTIC UNIVERSITY (US) | 2006-09-28 | — | — | WO | claimed |
| US-8765808-B2 | Treatment or prevention of cancer and precancerous disorders | CHS PHARMA, INC. (US) | 2014-07-01 | — | — | US | disclosed |
| US-8603985-B2 | Treatment or prevention of cancer and precancerous disorders | CHS Pharma, Inc (US) | 2013-12-10 | — | — | US | disclosed |
| EP-1865972-B1 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS | CHS PHARMA INC (US) | 2013-11-06 | — | — | EP | disclosed |
| US-8357720-B2 | Treatment or prevention of cancer and precancerous disorders | FLORIDA ATLANTIC UNIVERSITY (US) | 2013-01-22 | — | — | US | disclosed |
| US-8258181-B2 | Topically active agents to remove actinic keratoses and basal (BCC) and squamous (SCC) cell carcinomas using a combination of sulindac, its metabolites and derivatives with an oxidizing agent to generate reactive oxygen species nontoxic to normal cells; sulindac methionine sulfoxide/hydrogen peroxide | FLORIDA ATLANTIC UNIVERSITY (US) | 2012-09-04 | — | — | US | disclosed |
| US-20100260864-A1 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS | FLORIDA ATLANTIC UNIVERSITY (US) | 2010-10-14 | — | — | US | disclosed |
| US-20100069331-A1 | TREATMENT OR PREVENTION OF CANCER AND PRECANCEROUS DISORDERS | FLORIDA ATLANTIC UNIVERSITY (US) | 2010-03-18 | — | — | US | disclosed |
| US-20080119559-A1 | Topically active agents to remove actinic keratoses and basal (BCC) and squamous (SCC) cell carcinomas using a combination of sulindac, its metabolites and derivatives with an oxidizing agent to generate reactive oxygen species nontoxic to normal cells; sulindac methionine sulfoxide/hydrogen peroxide | FLORIDA ATLANTIC UNIVERSITY (US) | 2008-05-22 | — | — | US | disclosed |
| US-20060235080-A1 | Treatment or prevention of cancer and precancerous disorders | FLORIDA ATLANTIC UNIVERSITY (US) | 2006-10-19 | — | — | US | disclosed |
| WO-2003068324-A1 | ORGANIC CONTAMINANT REMOVAL FROM SLUDGE BY TARGETED CATALYSIS | MOTSENBOCKER MARVIN (US) | 2003-08-21 | — | — | WO | disclosed |
| US-5563132-A | Two-step cancer treatment method | BODANESS RICHARD S (US) | 1996-10-08 | — | — | US | disclosed |