Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP4K1 | Q92918 | 9/20 | 0.61 |
| ▸ | ABL1 | P00519 | 6/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.40 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.40 |
| ▸ | CYP17A1 | P05093 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22885183 | 0.88 | MAP4K1 (0.62) | MAP4K1ABL1 | |
| SCHEMBL22885580 | 0.86 | MAP4K1 (0.70) | MAP4K1ABL1 | |
| SCHEMBL38660013 | 0.85 | MAP4K1 (0.51) | MAP4K1ABL1CYP17A1 | |
| SCHEMBL22886186 | 0.84 | MAP4K1 (0.68) | MAP4K1ABL1 | |
| SCHEMBL30601018 | 0.84 | MAP4K1 (0.68) | MAP4K1ABL1 | |
| SCHEMBL20517012 | 0.84 | MAP4K1 (0.68) | MAP4K1ABL1 | |
| SCHEMBL30601010 | 0.83 | MAP4K1 (0.44) | MAP4K1CYP17A1 | |
| SCHEMBL22885630 | 0.81 | MAP4K1 (0.69) | MAP4K1ABL1 | |
| SCHEMBL20517694 | 0.81 | MAP4K1 (0.70) | MAP4K1ABL1 | |
| SCHEMBL30600827 | 0.81 | MAP4K1 (0.70) | MAP4K1ABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024411-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |