Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 3/20 | 0.40 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.40 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.32 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.32 |
| ▸ | CA1 | P00915 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.31 |
| ▸ | NT5E | P21589 | 1/20 | 0.31 |
| ▸ | CNR2 | P34972 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | LMNA | P02545 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20517233 | 1.00 | PDE4A (0.40) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL30600901 | 0.86 | PDE4A (0.38) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL20517546 | 0.86 | PDE4A (0.38) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL29069627 | 0.85 | PDE4A (0.40) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL30320884 | 0.85 | PDE4A (0.40) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL29099700 | 0.83 | GRM5 (0.34) | — | |
| SCHEMBL2748382 | 0.82 | PDE4A (0.49) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL31496161 | 0.82 | PDE4A (0.49) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL2749053 | 0.81 | PDE4A (0.39) | PDE4APDE4CPDE4DADORA2AADORA1 | |
| SCHEMBL1396954 | 0.81 | PDE4A (0.36) | PDE4APDE4CPDE4DADORA2AADORA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117024411-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2026-05-19 | — | — | CN | disclosed |
| CN-110709392-B | Isoquinoline as HPK1 inhibitor | 豪夫迈·罗氏有限公司 | 2023-09-29 | — | — | CN | disclosed |