Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 8/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | JAK3 | P52333 | 6/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 6/20 | 0.38 |
| ▸ | JAK2 | O60674 | 2/20 | 0.38 |
| ▸ | JAK1 | P23458 | 2/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2273795 | 1.00 | SYK (0.40) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL2275432 | 0.87 | JAK3 (0.43) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL3066002 | 0.87 | JAK3 (0.43) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL2277416 | 0.85 | MAP4K1 (0.44) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL2272098 | 0.84 | JAK3 (0.40) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL3066662 | 0.84 | JAK3 (0.40) | SYKCYP2C9JAK3MAPK1JAK2 | |
| SCHEMBL1635489 | 0.83 | MTOR (0.42) | SYKCYP2C9CYP2D6 | |
| SCHEMBL2276833 | 0.82 | MAP3K11 (0.44) | SYKMAPK1JAK2 | |
| SCHEMBL2276973 | 0.82 | MAP4K1 (0.42) | SYKCYP2C9JAK3MAPK1CYP2D6 | |
| SCHEMBL2277938 | 0.82 | MAP4K1 (0.52) | SYKJAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2245033-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. Hoffmann-La Roche AG (CH) | 2010-11-03 | — | — | EP | disclosed |
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | ROCHE PALO ALTO LLC | 2010-10-21 | — | — | US | disclosed |
| WO-2009106441-A1 | PYRROLOPYRAZINE KINASE INHIBITORS | F. HOFFMANN-LA ROCHE AG (CH) | 2009-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100267666-A1 | Pyrrolopyrazine kinase inhibitors | SYK, ZAP70, TYK2 | SYK 1/4885CYP2C9 3511/4885JAK3 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.