Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K1 | Q02750 | 14/20 | 0.74 |
| ▸ | RAF1 | P04049 | 13/20 | 0.74 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.74 |
| ▸ | BRAF | P15056 | 1/20 | 0.74 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.74 |
| ▸ | MAP2K5 | Q13163 | 1/20 | 0.74 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.58 |
| ▸ | HSD17B3 | P37058 | 3/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.49 |
| ▸ | GLA | P06280 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.49 |
| ▸ | ERAP1 | Q9NZ08 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | HPGD | P15428 | 1/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | CASP1 | P29466 | 1/20 | 0.44 |
| ▸ | CASP7 | P55210 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26613689 | 1.00 | MAP2K1 (0.74) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL29358292 | 0.85 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL29360048 | 0.85 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL960093 | 0.85 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL29515377 | 0.85 | MAP2K1 (1.00) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| SCHEMBL15901486 | 0.85 | RAF1 (0.54) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL959675 | 0.84 | MAP2K1 (0.98) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL959677 | 0.84 | MAP2K1 (0.98) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL963841 | 0.84 | MAP2K1 (0.98) | MAP2K1RAF1CYP2C9BRAFMAP2K2 | |
| Avutometinib SCHEMBL963844 | 0.84 | MAP2K1 (0.98) | MAP2K1RAF1CYP2C9BRAFMAP2K2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4701735-A1 | HETEROCYCLIC DERIVATIVE AS MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITOR | Nested Therapeutics, Inc. (US) | 2026-03-04 | — | — | EP | disclosed |
| EP-4514471-A1 | HETEROCYCLIC DERIVATIVES AS MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | Nested Therapeutics, Inc. (US) | 2025-03-05 | — | — | EP | disclosed |
| CN-119487021-A | Heterocyclic derivatives as inhibitors of mitogen-activated protein kinase (MEK) | 内斯特治疗公司 | 2025-02-18 | — | — | CN | disclosed |
| WO-2024226579-A9 | HETEROCYCLIC DERIVATIVE AS MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITOR | NESTED THERAPEUTICS, INC. (US) | 2024-12-26 | — | — | WO | disclosed |
| WO-2024226579-A1 | HETEROCYCLIC DERIVATIVE AS MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITOR | NESTED THERAPEUTICS, INC. (US) | 2024-10-31 | — | — | WO | disclosed |
| WO-2023211812-A1 | HETEROCYCLIC DERIVATIVES AS MITOGEN-ACTIVATED PROTEIN KINASE (MEK) INHIBITORS | NESTED THERAPEUTICS, INC. (US) | 2023-11-02 | — | — | WO | disclosed |