Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 15/20 | 0.54 |
| ▸ | FLT3 | P36888 | 4/20 | 0.54 |
| ▸ | JAK1 | P23458 | 10/20 | 0.47 |
| ▸ | TYK2 | P29597 | 9/20 | 0.47 |
| ▸ | JAK3 | P52333 | 5/20 | 0.47 |
| ▸ | KDR | P35968 | 1/20 | 0.47 |
| ▸ | STAT1 | P42224 | 1/20 | 0.47 |
| ▸ | EGFR | P00533 | 1/20 | 0.47 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.47 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.43 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29097561 | 1.00 | JAK2 (0.54) | JAK2FLT3JAK1TYK2JAK3 | |
| SCHEMBL23276667 | 0.84 | JAK1 (0.67) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL23299607 | 0.84 | JAK1 (0.67) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL29097711 | 0.84 | ALK (0.49) | JAK2FLT3EGFR | |
| SCHEMBL29097572 | 0.80 | MAP3K7 (0.47) | JAK2TYK2JAK3EGFR | |
| SCHEMBL29097558 | 0.79 | JAK2 (0.53) | JAK2FLT3JAK1JAK3EGFR | |
| SCHEMBL30621971 | 0.79 | JAK2 (0.53) | JAK2FLT3JAK1JAK3EGFR | |
| SCHEMBL29097710 | 0.77 | JAK1 (0.55) | JAK2JAK1TYK2JAK3KDR | |
| SCHEMBL28322770 | 0.76 | JAK2 (0.71) | JAK2FLT3JAK3EGFRMKNK1 | |
| SCHEMBL23277056 | 0.73 | JAK1 (0.64) | JAK2JAK1TYK2JAK3KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4745132-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | Technoderma Medicines Inc. (CN) | 2026-05-20 | — | — | EP | disclosed |
| WO-2025011447-A1 | PYRIMIDINAMINE NUAK INHIBITOR, AND PREPARATION METHOD THEREFOR AND USE THEREOF | 特科罗生物科技(成都)有限公司 | 2025-01-16 | — | — | WO | disclosed |
| CN-116903592-A | Pyrimidine amine NUAK inhibitor and preparation method and application thereof | 特科罗生物科技(成都)有限公司 | 2023-10-20 | — | — | CN | disclosed |