SCHEMBL30628271

SCHEMBL30628271

Cc1cccc(C(F)(F)C(=O)NCc2ccc3c(c2)CN([C@@H]2CCC(=O)NC2=O)C3=O)c1

nearest known ligand 0.76

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 11/20 0.76
GSPT1 P15170 2/20 0.76
DDB1 Q16531 2/20 0.76
CYP2C19 P33261 1/20 0.76
KCNH2 Q12809 1/20 0.76
IKZF3 Q9UKT9 1/20 0.59
CSNK1A1 P48729 5/20 0.57
IKZF1 Q13422 3/20 0.49
IKZF2 Q9UKS7 9/20 0.47

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL29372964 1.00 CRBN (0.76) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL17420456 1.00 CRBN (0.76) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL29375056 0.91 CRBN (0.77) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL17420796 0.91 CRBN (0.77) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL29375759 0.91 CRBN (0.77) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL30628240 0.91 CRBN (0.77) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL17420666 0.91 CRBN (0.77) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL17420533 0.91 CRBN (0.85) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL17420783 0.91 CRBN (0.84) CRBNGSPT1DDB1CYP2C19KCNH2
SCHEMBL17420768 0.91 CRBN (0.84) CRBNGSPT1DDB1CYP2C19KCNH2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111170991-B Antiproliferative compounds and methods of synthesis thereof 细胞基因公司 2023-10-31 CN disclosed