Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 6/20 | 0.37 |
| ▸ | MTOR | P42345 | 5/20 | 0.37 |
| ▸ | PIK3CD | O00329 | 5/20 | 0.37 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.37 |
| ▸ | ABL1 | P00519 | 4/20 | 0.37 |
| ▸ | EGFR | P00533 | 4/20 | 0.37 |
| ▸ | HCK | P08631 | 4/20 | 0.37 |
| ▸ | SRC | P12931 | 4/20 | 0.37 |
| ▸ | KDR | P35968 | 4/20 | 0.37 |
| ▸ | PIK3CB | P42338 | 4/20 | 0.37 |
| ▸ | EPHB4 | P54760 | 4/20 | 0.37 |
| ▸ | PRKDC | P78527 | 4/20 | 0.37 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.36 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.36 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.36 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.36 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.36 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.36 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.34 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30309561 | 0.81 | RPS6KA3 (0.35) | PIK3CAMTORPIK3CDPIK3CGABL1 | |
| SCHEMBL25775897 | 0.74 | ADORA2A (0.35) | PIK3CAMTORPIK3CDPIK3CGABL1 | |
| SCHEMBL30632250 | 0.74 | EGFR (0.38) | PIK3CAMTORPIK3CDPIK3CGABL1 | |
| SCHEMBL21344922 | 0.70 | CDK6 (0.43) | — | |
| SCHEMBL30309518 | 0.69 | RPS6KA3 (0.37) | EGFRADORA2ARPS6KA3CDC7TLR7 | |
| SCHEMBL30818384 | 0.68 | CDK4 (0.55) | EGFRKDRBRAF | |
| SCHEMBL16892106 | 0.68 | CDK4 (0.55) | EGFRKDRBRAF | |
| SCHEMBL29402856 | 0.68 | CDK4 (0.55) | EGFRKDRBRAF | |
| SCHEMBL18081420 | 0.68 | CDK4 (0.54) | PIK3CAMTORRICTORRPTORMAPKAP1 | |
| SCHEMBL19966562 | 0.67 | IRAK4 (0.39) | PIK3CAMTORPIK3CDPIK3CGABL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110156754-B | Inhibition of protein kinase by trisubstituted pyrimidine derivative | 杭州百诚医药科技股份有限公司 | 2023-10-03 | — | — | CN | disclosed |