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SCHEMBL30632528

SCHEMBL30632528

Cc1ncsc1-c1ccc([C@H](C)NC(=O)[C@@H]2C[C@@H](O)CN2C(=O)[C@@H](c2cc(N3CCC4(CC3)CC(Oc3ccc5nnc(-c6ccccc6O)cc5c3)C4)no2)C(C)C)cc1

nearest known ligand 0.58

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
▸ VHL P40337 16/20 0.58
▸ SMARCA2 P51531 7/20 0.58
▸ SMARCA4 P51532 7/20 0.58
▸ PBRM1 Q86U86 1/20 0.41
▸ LRRK2 Q5S007 2/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL30632489 1.00 VHL (0.58) VHLSMARCA2SMARCA4PBRM1LRRK2
SCHEMBL26685027 1.00 VHL (0.58) VHLSMARCA2SMARCA4PBRM1LRRK2
SCHEMBL26685035 1.00 VHL (0.58) VHLSMARCA2SMARCA4PBRM1LRRK2
SCHEMBL26685023 1.00 VHL (0.58) VHLSMARCA2SMARCA4PBRM1LRRK2
SCHEMBL30632433 0.92 VHL (0.58) VHLSMARCA2SMARCA4
SCHEMBL26685116 0.92 VHL (0.58) VHLSMARCA2SMARCA4
SCHEMBL26684905 0.92 VHL (0.58) VHLSMARCA2SMARCA4
SCHEMBL30632493 0.92 VHL (0.58) VHLSMARCA2SMARCA4
SCHEMBL26684907 0.92 VHL (0.58) VHLSMARCA2SMARCA4
SCHEMBL26683244 0.87 VHL (0.58) VHLSMARCA2SMARCA4

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-4522278-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES Foghorn Therapeutics Inc. (US) 2025-03-19 — — EP disclosed
WO-2023220129-A1 BENZOYPARAZINE PYRAZINES ANE THEIR USES FOGHORN THERAPEUTICS INC. (US) 2023-11-16 — — WO disclosed
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