Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK1 | P23458 | 4/20 | 0.39 |
| ▸ | JAK2 | O60674 | 2/20 | 0.39 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.38 |
| ▸ | RET | P07949 | 1/20 | 0.37 |
| ▸ | BTK | Q06187 | 5/20 | 0.36 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.36 |
| ▸ | CACNB4 | O00305 | 1/20 | 0.36 |
| ▸ | CACNA1A | O00555 | 1/20 | 0.36 |
| ▸ | CACNA1G | O43497 | 1/20 | 0.36 |
| ▸ | CACNG3 | O60359 | 1/20 | 0.36 |
| ▸ | CACNA1F | O60840 | 1/20 | 0.36 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.36 |
| ▸ | CACNA2D1 | P54289 | 1/20 | 0.36 |
| ▸ | CACNG7 | P62955 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNA1D | Q01668 | 1/20 | 0.36 |
| ▸ | CACNB1 | Q02641 | 1/20 | 0.36 |
| ▸ | CACNG1 | Q06432 | 1/20 | 0.36 |
| ▸ | CACNB2 | Q08289 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26670663 | 0.89 | CHEK1 (0.35) | KCNH2 | |
| SCHEMBL30634783 | 0.86 | AURKA (0.36) | JAK1JAK2KCNH2RETBTK | |
| SCHEMBL24978200 | 0.85 | BTK (0.40) | JAK1JAK2RETBTKPIK3CD | |
| SCHEMBL30101520 | 0.85 | BTK (0.40) | JAK1JAK2RETBTKPIK3CD | |
| SCHEMBL24936165 | 0.84 | CHEK1 (0.46) | JAK1JAK2KCNH2RETBTK | |
| SCHEMBL30634785 | 0.82 | KCNH2 (0.63) | KCNH2 | |
| SCHEMBL24978460 | 0.80 | PIK3CD (0.36) | JAK1JAK2RETBTKPIK3CD | |
| SCHEMBL30101588 | 0.80 | PIK3CD (0.36) | JAK1JAK2RETBTKPIK3CD | |
| SCHEMBL30634798 | 0.80 | PIK3CD (0.38) | JAK1JAK2KCNH2RETBTK | |
| SCHEMBL30634781 | 0.79 | JAK1 (0.38) | JAK1JAK2BTKPIK3CDCACNB4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4532486-A1 | PYRIDINE CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | Boundless Bio, Inc. (US) | 2025-04-09 | — | — | EP | disclosed |
| CN-119546588-A | Pyridine checkpoint kinase 1 (CHK 1) inhibitors and uses thereof | 无界生物公司 | 2025-02-28 | — | — | CN | disclosed |
| WO-2023230477-A1 | PYRIDINE CHECKPOINT KINASE 1 (CHK1) INHIBITORS AND USES THEREOF | BOUNDLESS BIO, INC. (US) | 2023-11-30 | — | — | WO | disclosed |