Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 12/20 | 0.60 |
| ▸ | BRAF | P15056 | 5/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.59 |
| ▸ | EGFR | P00533 | 1/20 | 0.59 |
| ▸ | KRAS | P01116 | 1/20 | 0.59 |
| ▸ | RAF1 | P04049 | 1/20 | 0.59 |
| ▸ | PGR | P06401 | 1/20 | 0.59 |
| ▸ | RET | P07949 | 1/20 | 0.59 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.59 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.59 |
| ▸ | ARAF | P10398 | 1/20 | 0.59 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.59 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.59 |
| ▸ | FECH | P22830 | 1/20 | 0.59 |
| ▸ | KDR | P35968 | 1/20 | 0.59 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.59 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.59 |
| ▸ | NEK2 | P51955 | 1/20 | 0.59 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23098869 | 1.00 | MAP2K4 (0.60) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL995658 | 0.84 | BRAF (0.68) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL30636737 | 0.82 | MAP2K4 (0.60) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL23098868 | 0.82 | MAP2K4 (0.60) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21223100 | 0.82 | MAP2K4 (0.59) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL23098909 | 0.81 | MAP2K4 (0.68) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL23098881 | 0.81 | MAP2K4 (0.61) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21222990 | 0.81 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21222883 | 0.80 | MAP2K4 (0.60) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21223009 | 0.80 | MAP2K4 (0.58) | MAP2K4BRAFRIPK2ABCB11EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111788195-B | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2023-11-21 | — | — | CN | disclosed |