Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAP2K4 | P45985 | 16/20 | 0.75 |
| ▸ | BRAF | P15056 | 2/20 | 0.62 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.62 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.62 |
| ▸ | EGFR | P00533 | 1/20 | 0.62 |
| ▸ | KRAS | P01116 | 1/20 | 0.62 |
| ▸ | RAF1 | P04049 | 1/20 | 0.62 |
| ▸ | PGR | P06401 | 1/20 | 0.62 |
| ▸ | RET | P07949 | 1/20 | 0.62 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.62 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.62 |
| ▸ | ARAF | P10398 | 1/20 | 0.62 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.62 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.62 |
| ▸ | FECH | P22830 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | MAP2K2 | P36507 | 1/20 | 0.62 |
| ▸ | TGFBR2 | P37173 | 1/20 | 0.62 |
| ▸ | NEK2 | P51955 | 1/20 | 0.62 |
| ▸ | MAP2K1 | Q02750 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21223018 | 1.00 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL30694412 | 0.93 | MAP2K4 (0.66) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21224028 | 0.93 | MAP2K4 (0.66) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL30694407 | 0.93 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL23098899 | 0.93 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21223091 | 0.93 | MAP2K4 (0.76) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL30636753 | 0.93 | MAP2K4 (0.76) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21222990 | 0.92 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL23098883 | 0.92 | MAP2K4 (0.66) | MAP2K4BRAFRIPK2ABCB11EGFR | |
| SCHEMBL21222913 | 0.92 | MAP2K4 (0.75) | MAP2K4BRAFRIPK2ABCB11EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3746437-B1 | PROTEIN KINASE MKK4 INHIBITORS FOR PROMOTING LIVER REGENERATION OR REDUCING OR PREVENTING HEPATOCYTE DEATH | HEPAREGENIX GMBH (DE) | 2024-08-21 | — | — | EP | claimed |
| CN-111788195-B | Protein kinase MKK4 inhibitors for promoting liver regeneration or reducing or preventing hepatocyte death | 海帕瑞吉尼克斯股份有限公司 | 2023-11-21 | — | — | CN | disclosed |