Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIMK1 | P53667 | 3/20 | 0.49 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.43 |
| ▸ | TDO2 | P48775 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.42 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.42 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.42 |
| ▸ | CYP2A6 | P11509 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | PI4KB | Q9UBF8 | 2/20 | 0.40 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.40 |
| ▸ | PI4KA | P42356 | 1/20 | 0.40 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.40 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.40 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27953881 | 1.00 | LIMK1 (0.49) | LIMK1CYP11B1TDO2MEN1PSIP1 | |
| SCHEMBL30639400 | 0.86 | LIMK1 (0.46) | LIMK1PI4KBPI4KAPI4K2BPI4K2A | |
| SCHEMBL30639393 | 0.83 | LIMK1 (0.49) | LIMK1PI4KBPIK3CAPI4KAPI4K2B | |
| SCHEMBL30639391 | 0.82 | LIMK1 (0.63) | LIMK1PI4KBPI4KAPI4K2BPI4K2A | |
| SCHEMBL30639399 | 0.81 | PIK3CA (0.43) | LIMK1ALDH1A1PI4KBPIK3CAPI4KA | |
| SCHEMBL26259989 | 0.76 | CYP2A6 (0.64) | CYP11B1TDO2MEN1PSIP1AXL | |
| SCHEMBL28138757 | 0.76 | CYP11B1 (0.53) | CYP11B1TDO2MEN1PSIP1AXL | |
| SCHEMBL19053831 | 0.74 | KDM4E (0.54) | TDO2MEN1PSIP1AXLMKNK1 | |
| SCHEMBL29723496 | 0.74 | LIMK1 (0.53) | LIMK1TDO2CYP2A6CYP1A2CYP3A4 | |
| SCHEMBL29576461 | 0.73 | MAP4K4 (0.59) | TDO2MEN1PSIP1AXLMKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-117043144-A | 8-ring-substituted quinazoline derivatives as LPA receptor 2 inhibitors | 奇斯药制品公司 | 2023-11-10 | — | — | CN | claimed |
| US-20240190860-A1 | 8-CYCLO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | CHIESI FARMACEUTICI S.P.A. (IT) | 2024-06-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240190860-A1 | 8-CYCLO-SUBSTITUTED QUINAZOLINE DERIVATIVES AS LPA RECEPTOR 2 INHIBITORS | LPAR2, LPAR5, LPAR1 | LIMK1 2781/4885CYP11B1 2699/4885TDO2 3244/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.