Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KRAS | P01116 | 3/20 | 0.68 |
| ▸ | FNTA | P49354 | 3/20 | 0.38 |
| ▸ | FNTB | P49356 | 3/20 | 0.38 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.37 |
| ▸ | STS | P08842 | 4/20 | 0.37 |
| ▸ | SHMT2 | P34897 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | TERT | O14746 | 1/20 | 0.36 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16129263 | 1.00 | KRAS (0.68) | KRASFNTAFNTBUSP30STS | |
| SCHEMBL20260100 | 0.89 | KRAS (0.55) | KRASFNTAFNTBUSP30STS | |
| SCHEMBL21458760 | 0.89 | KRAS (0.74) | KRASFNTAFNTBUSP30STS | |
| SCHEMBL16098539 | 0.84 | KRAS (0.78) | KRASSHMT2 | |
| SCHEMBL16098252 | 0.84 | KRAS (0.48) | KRASFNTAFNTBSTSSHMT2 | |
| SCHEMBL30642275 | 0.84 | KRAS (0.48) | KRASSTSSHMT2MEN1KMT2A | |
| SCHEMBL16098954 | 0.84 | KRAS (0.48) | KRASSTSSHMT2MEN1KMT2A | |
| SCHEMBL16122856 | 0.83 | KRAS (0.76) | KRASSHMT2 | |
| SCHEMBL16093602 | 0.82 | KRAS (0.46) | KRASSTSSHMT2 | |
| SCHEMBL16102313 | 0.82 | KRAS (0.46) | KRASSTSSHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-RE50527-E1 | Covalent inhibitors of KRAS G12C | ARAXES PHARMA LLC (US) | 2025-08-12 | — | — | US | disclosed |
| EP-3401314-B1 | COVALENT INHIBITORS OF KRAS G12C | ARAXES PHARMA LLC (US) | 2023-11-08 | — | — | EP | disclosed |