⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27516947 | 0.78 | — | — | |
| SCHEMBL12004134 | 0.73 | — | — | |
| SCHEMBL12004136 | 0.73 | — | — | |
| SCHEMBL14734493 | 0.71 | — | — | |
| SCHEMBL6888708 | 0.71 | — | — | |
| SCHEMBL16729957 | 0.71 | — | — | |
| SCHEMBL13635979 | 0.69 | MGAM (0.48) | — | |
| SCHEMBL18296650 | 0.64 | KDM4E (0.36) | — | |
| SCHEMBL13711450 | 0.61 | — | — | |
| SCHEMBL28254075 | 0.61 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 46 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6166173-A | Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same | GUILFORD PHARMACEUTICALS INC. (US) | 2000-12-26 | — | — | US | claimed |
| US-8455500-B2 | 3-hydroxy-5-arylisoxazole derivative | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2013-06-04 | — | — | US | disclosed |
| US-20130023688-A1 | PHOSPHORUS-CONTAINING COMPOUNDS WITH POLYMERIC CHAINS, AND METHODS OF MAKING AND USING THE SAME | EISAI INC. (US) | 2013-01-24 | — | — | US | disclosed |
| EP-2495238-A1 | NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE | Mochida Pharmaceutical Co., Ltd. (JP) | 2012-09-05 | — | — | EP | disclosed |
| US-8258255-B2 | Phosphorus-containing compounds with polymeric chains, and methods of making and using the same | EISAI INC. (US) | 2012-09-04 | — | — | US | disclosed |
| US-20120220772-A1 | NOVEL 3-HYDROXY-5-ARYLISOXAZOLE DERIVATIVE | MOCHIDA PHARMACEUTICAL CO., LTD. (JP) | 2012-08-30 | — | — | US | disclosed |
| US-20100267924-A1 | Phosphorus-Containing Compounds with Polymeric Chains, and Methods of Making and Using the Same | EISAI INC. (US) | 2010-10-21 | — | — | US | disclosed |
| US-7674875-B2 | Phosphorus-containing compounds with polymeric chains, and methods of making and using the same | EISAI INC. (US) | 2010-03-09 | — | — | US | disclosed |
| US-20090247778-A1 | Star polymer such as of a polylactone based on a central phosphorus atom derived from phosphorus oxychloride (POCl3) or ethyl dichlorophosphate; biodegradable and/or biocompatible; sustained release drug delivery; reverse thermal gelation | EISAI CORPORATION OF NORTH AMERICA (US) | 2009-10-01 | — | — | US | disclosed |
| US-7479535-B2 | Phosphorous-containing compounds with polymeric chains, and methods of making and using the same | GUILFORD PHARMACEUTICALS, INC. (US) | 2009-01-20 | — | — | US | disclosed |
| US-20020028911-A1 | Ethyl or hexyl dichlorophosphate or dichlorophosphonate reacted with a polyester prepolymer | EISAI INC. | 2002-03-07 | — | — | US | disclosed |
| US-6350464-B1 | COMPOSITION FOR INTRAPERITONEAL ADMINISTRATION TO TREAT MAMMAL HAVING OVARIAN CANCER COMPRISING ANTINEOPLASTIC AGENT AND BIODEGRADABLE POLYPHOSPHOESTER POLYMER, PROVIDING EXTENDED RELEASE OF AGENT AND INCREASED SURVIVAL RATE | GUILFORD PHARMACEUTICALS, INC. | 2002-02-26 | — | — | US | disclosed |
| WO-2002005800-A2 | COMPOSITIONS FOR SUSTAINED RELEASE OF ANALGESIC AGENTS, AND METHODS OF MAKING AND USING THE SAME | GUILFORD PHARMACEUTICALS, INC. (US) | 2002-01-24 | — | — | WO | disclosed |
| WO-2002004544-A2 | POLYMERS AND POLYMERIZATION PROCESSES | GUILFORD PHARMACEUTICALS (US) | 2002-01-17 | — | — | WO | disclosed |
| WO-2002003957-A2 | COMPOSITIONS FOR SUSTAINED RELEASE OF ANTINEOPLASTIC TAXANES, AND METHODS OF MAKING AND USING THE SAME | GUILFORD PHARMACEUTICALS, INC. (US) | 2002-01-17 | — | — | WO | disclosed |
| US-20010038849-A1 | Methods for treating ovarian cancer, poly (phosphoester) compositions, and biodegradable articles for same | EISAI INC. | 2001-11-08 | — | — | US | disclosed |
| EP-1096957-A1 | METHODS AND REAGENTS FOR INTRAMUSCULAR DELIVERY OF NUCLEIC ACIDS | Johns Hopkins University School of Medicine (US) | 2001-05-09 | — | — | EP | disclosed |
| US-6166173-A | Biodegradable polymers chain-extended by phosphates, compositions, articles and methods for making and using the same | GUILFORD PHARMACEUTICALS INC. (US) | 2000-12-26 | — | — | US | disclosed |
| WO-1999065531-A9 | POLYMERS FOR DELIVERY OF NUCLEIC ACIDS | UNIV JOHNS HOPKINS MED (US) | 2000-04-27 | — | — | WO | disclosed |
| WO-1999065531-A1 | POLYMERS FOR DELIVERY OF NUCLEIC ACIDS | JOHNS HOPKINS UNIVERSITY SCHOOL OF MEDICINE (US) | 1999-12-23 | — | — | WO | disclosed |