Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCRTR1 | O43613 | 18/20 | 1.00 |
| ▸ | HCRTR2 | O43614 | 18/20 | 1.00 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | BLM | P54132 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2707045 | 1.00 | HCRTR1 (1.00) | HCRTR1HCRTR2ALDH1A1LMNAMEN1 | |
| SCHEMBL4483251 | 0.93 | HCRTR1 (0.86) | HCRTR1HCRTR2ALDH1A1LMNA | |
| SCHEMBL4486475 | 0.91 | HCRTR1 (0.84) | HCRTR1HCRTR2ALDH1A1LMNAMEN1 | |
| SCHEMBL4485600 | 0.90 | HCRTR1 (0.81) | HCRTR1HCRTR2ALDH1A1LMNA | |
| SCHEMBL4481929 | 0.89 | HCRTR1 (0.79) | HCRTR1HCRTR2ALDH1A1LMNAMEN1 | |
| SCHEMBL4482886 | 0.89 | HCRTR1 (0.79) | HCRTR1HCRTR2 | |
| SCHEMBL4474735 | 0.89 | HCRTR1 (0.79) | HCRTR1HCRTR2ALDH1A1LMNAMEN1 | |
| SCHEMBL4499834 | 0.88 | HCRTR1 (0.78) | HCRTR1HCRTR2MEN1CYP3A4CYP2D6 | |
| SCHEMBL4485073 | 0.87 | HCRTR1 (0.77) | HCRTR1HCRTR2ALDH1A1LMNAMEN1 | |
| SCHEMBL4493129 | 0.86 | HCRTR1 (1.00) | HCRTR1HCRTR2ALDH1A1LMNAMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2023218023-A1 | THIAZOLOARYL-METHYL SUBSTITUTED CYCLIC HYDRAZINE-N-CARBOXAMIDE DERIVATIVES | IDORSIA PHARMACEUTICALS LTD (CH) | 2023-11-16 | — | — | WO | disclosed |