Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRM5 | P41594 | 2/20 | 0.39 |
| ▸ | ESR1 | P03372 | 1/20 | 0.32 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.32 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.31 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.31 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.31 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.31 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.31 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.31 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.31 |
| ▸ | TDP2 | O95551 | 1/20 | 0.30 |
| ▸ | NSD2 | O96028 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30646092 | 0.85 | GRM5 (0.36) | GRM5TDP2NSD2 | |
| SCHEMBL30646147 | 0.84 | GRM5 (0.36) | GRM5ESR1ESR2GRIN2DGRIN3B | |
| SCHEMBL30646090 | 0.82 | GRM5 (0.45) | GRM5ESR1ESR2 | |
| SCHEMBL4683297 | 0.81 | GRM5 (0.55) | GRM5TDP2NSD2 | |
| SCHEMBL30646083 | 0.81 | GRM5 (0.55) | GRM5TDP2NSD2 | |
| SCHEMBL16801069 | 0.77 | CYP19A1 (0.36) | GRM5ESR1ESR2GRIN2DGRIN3B | |
| SCHEMBL30646085 | 0.77 | GRM5 (0.39) | GRM5TDP2NSD2 | |
| SCHEMBL31668731 | 0.76 | GRM5 (0.37) | GRM5TDP2NSD2 | |
| SCHEMBL4433359 | 0.76 | GRM5 (0.34) | GRM5 | |
| SCHEMBL13669670 | 0.76 | MEN1 (0.34) | GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4543437-A1 | 3-?HSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2025-04-30 | — | — | EP | disclosed |
| WO-2023250480-A1 | 3-βHSD1 INHIBITORS AND COMPOSITIONS AND USES THEREOF | THE CLEVELAND CLINIC FOUNDATION (US) | 2023-12-28 | — | — | WO | disclosed |