Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.58 |
| ▸ | MAPK1 | P28482 | 8/20 | 0.43 |
| ▸ | CDK2 | P24941 | 4/20 | 0.43 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.43 |
| ▸ | IGF1R | P08069 | 1/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.41 |
| ▸ | CCND3 | P30281 | 2/20 | 0.41 |
| ▸ | CCNK | O75909 | 1/20 | 0.41 |
| ▸ | CDK9 | P50750 | 1/20 | 0.41 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.41 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 2/20 | 0.40 |
| ▸ | JAK3 | P52333 | 2/20 | 0.40 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.40 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND1 | P24385 | 1/20 | 0.40 |
| ▸ | CCND2 | P30279 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640054 | 1.00 | MAPT (0.58) | MAPTMAPK1CDK2PDGFRBIGF1R | |
| SCHEMBL26640866 | 0.87 | MAPT (0.65) | MAPTMAPK1CDK2PDGFRBDDB1 | |
| SCHEMBL26640694 | 0.85 | MAPT (0.61) | MAPTMAPK1CDK2PDGFRBIGF1R | |
| SCHEMBL30648725 | 0.84 | MAPT (0.47) | MAPTMAPK1IGF1RESR2 | |
| SCHEMBL26640165 | 0.84 | MAPT (0.47) | MAPTMAPK1IGF1RESR2 | |
| SCHEMBL26640185 | 0.83 | MAPT (0.56) | MAPTMAPK1CDK2PDGFRBIGF1R | |
| SCHEMBL26640202 | 0.83 | MAPT (0.62) | MAPTMAPK1CDK2PDGFRBIGF1R | |
| SCHEMBL12497520 | 0.83 | MAPK1 (0.61) | MAPTMAPK1CDK2PDGFRBIGF1R | |
| SCHEMBL26640500 | 0.82 | MAPT (0.56) | MAPTMAPK1CDK2PDGFRBIGF1R | |
| SCHEMBL26640194 | 0.82 | MAPT (0.56) | MAPTMAPK1CDK2PDGFRBIGF1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |