Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.56 |
| ▸ | CDK2 | P24941 | 6/20 | 0.51 |
| ▸ | CCNA2 | P20248 | 4/20 | 0.51 |
| ▸ | AURKA | O14965 | 2/20 | 0.51 |
| ▸ | CCNA1 | P78396 | 2/20 | 0.51 |
| ▸ | PTK2 | Q05397 | 4/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.47 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.47 |
| ▸ | JAK2 | O60674 | 6/20 | 0.47 |
| ▸ | BRD4 | O60885 | 3/20 | 0.47 |
| ▸ | JAK3 | P52333 | 4/20 | 0.47 |
| ▸ | JAK1 | P23458 | 1/20 | 0.47 |
| ▸ | CCNK | O75909 | 1/20 | 0.45 |
| ▸ | CCND3 | P30281 | 1/20 | 0.45 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.45 |
| ▸ | EGFR | P00533 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640628 | 1.00 | MAPT (0.56) | MAPTCDK2CCNA2AURKACCNA1 | |
| SCHEMBL26640167 | 0.89 | MAPT (0.64) | MAPTCDK2CCNA2AURKACCNA1 | |
| SCHEMBL26641017 | 0.86 | MAPT (0.56) | MAPTCDK2EGFR | |
| SCHEMBL26640702 | 0.86 | MAPT (0.53) | MAPTCDK2CCNA2AURKACCNA1 | |
| SCHEMBL30648637 | 0.86 | MAPT (0.53) | MAPTCDK2CCNA2AURKACCNA1 | |
| SCHEMBL26640403 | 0.85 | MAPT (0.58) | MAPTCDK2CCNA2PTK2JAK2 | |
| SCHEMBL30648732 | 0.85 | MAPT (0.58) | MAPTCDK2CCNA2PTK2JAK2 | |
| SCHEMBL26640202 | 0.85 | MAPT (0.62) | MAPTCDK2PTK2JAK2JAK3 | |
| SCHEMBL26640456 | 0.84 | MAPT (0.64) | MAPTCDK2PTK2JAK2JAK3 | |
| SCHEMBL30648697 | 0.84 | MAPT (0.55) | MAPTCDK2CCNA2AURKACCNA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |