Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 8/20 | 0.43 |
| ▸ | JAK3 | P52333 | 7/20 | 0.43 |
| ▸ | PTK2 | Q05397 | 6/20 | 0.43 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.42 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.42 |
| ▸ | IGF1R | P08069 | 1/20 | 0.41 |
| ▸ | WEE1 | P30291 | 1/20 | 0.40 |
| ▸ | ULK1 | O75385 | 2/20 | 0.39 |
| ▸ | ULK2 | Q8IYT8 | 2/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 3/20 | 0.38 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | CDK2 | P24941 | 1/20 | 0.38 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26640352 | 1.00 | MAPT (0.51) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL26640194 | 0.85 | MAPT (0.56) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL26640413 | 0.85 | MAPT (0.51) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL30648741 | 0.85 | MAPT (0.51) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL30648669 | 0.85 | MAPT (0.55) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL26640747 | 0.85 | MAPT (0.55) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL26640652 | 0.83 | MAPT (0.62) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL26640811 | 0.83 | MAPT (0.62) | MAPTJAK2JAK3PTK2DDB1 | |
| SCHEMBL30648653 | 0.82 | WEE1 (0.38) | MAPTJAK2WEE1 | |
| SCHEMBL26640202 | 0.80 | MAPT (0.62) | MAPTJAK2JAK3PTK2DDB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4522618-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | Merck Patent GmbH (DE) | 2025-03-19 | — | — | EP | disclosed |
| WO-2023220541-A1 | TETRAHYDROPYRIDO[3,4-D]PYRIMIDINES COMPOUNDS AS HPK1 INHIBITORS | MERCK PATENT GMBH (DE) | 2023-11-16 | — | — | WO | disclosed |